Ursodeoxycholic acid CAS 128-13-2

Ursodeoxycholic acid (UDCA) is a bile acid that is naturally produced by the liver and found in small amounts in human bile. It is also available as a medication and is commonly prescribed for various liver and gallbladder-related conditions. UDCA is classified as a hepatoprotective and choleretic agent, meaning it helps protect the liver and promotes the flow of bile.

1. Dissolution of Gallstones: Ursodeoxycholic acid is often prescribed to dissolve certain types of gallstones, specifically cholesterol gallstones. It works by reducing the cholesterol content in bile and modifying the composition of bile to promote the dissolution of gallstones over time. This treatment is most effective for small, radiolucent (visible on X-ray) gallstones.

2. Primary Biliary Cholangitis (PBC): Ursodeoxycholic acid is the mainstay treatment for primary biliary cholangitis (PBC), an autoimmune liver disease characterized by the destruction of small bile ducts in the liver. UDCA helps improve liver function, slow the progression of the disease, and alleviate symptoms such as fatigue and itching.

3. Primary Sclerosing Cholangitis (PSC): Ursodeoxycholic acid may also be used as a treatment option for primary sclerosing cholangitis (PSC), a chronic inflammatory condition that affects the bile ducts in the liver. While its efficacy in PSC is less well-established compared to PBC, UDCA may be prescribed to improve liver function and alleviate symptoms.

4. Cholestasis of Pregnancy: Ursodeoxycholic acid is sometimes used to manage cholestasis of pregnancy, a condition characterized by reduced bile flow and elevated levels of bile acids in the bloodstream. UDCA can help improve liver function, relieve symptoms such as itching, and reduce the risk of complications for both the mother and baby.

5. Other Potential Uses: Ursodeoxycholic acid has been investigated for its potential benefits in other liver conditions, such as non-alcoholic fatty liver disease (NAFLD), drug-induced liver injury, and certain forms of liver transplantation.

It's important to note that the use of ursodeoxycholic acid should be under the guidance and prescription of a healthcare professional. The dosage and treatment duration may vary depending on the specific condition being treated. If you have specific medical concerns or questions about ursodeoxycholic acid, it is advisable to consult with a healthcare professional for personalized advice based on your individual circumstances.

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