Fleroxacin CAS 79660-72-3

Fleroxacin is an antibiotic belonging to the fluoroquinolone class of drugs. It is used to treat various bacterial infections caused by susceptible organisms. Fleroxacin works by inhibiting the bacterial DNA gyrase and topoisomerase IV enzymes, which are essential for bacterial DNA replication and repair. By interfering with these enzymes, fleroxacin disrupts the bacterial cell's ability to divide and multiply, ultimately leading to the death of the bacteria.

Fleroxacin, a fluoroquinolone antibiotic, is used to treat various bacterial infections caused by susceptible microorganisms. Some of the main uses of fleroxacin include:

1. Urinary Tract Infections (UTIs): Fleroxacin is commonly prescribed for uncomplicated and complicated UTIs, including infections of the bladder (cystitis) and the kidneys (pyelonephritis). It is effective against many Gram-negative bacteria commonly associated with UTIs, such as Escherichia coli.

2. Respiratory Tract Infections: Fleroxacin is used to treat bacterial infections of the respiratory tract, including bronchitis and pneumonia caused by susceptible pathogens. It can be effective against certain Gram-negative and atypical bacteria.

3. Gastrointestinal Infections: Fleroxacin may be prescribed for bacterial gastroenteritis caused by susceptible bacteria, helping to alleviate symptoms such as diarrhea and abdominal pain.

4. Skin and Soft Tissue Infections: Fleroxacin can be used to treat bacterial skin infections, such as cellulitis or infected wounds, when the causative bacteria are susceptible to the antibiotic.

5. Sexually Transmitted Infections (STIs): Fleroxacin has been used in the treatment of certain STIs, including gonorrhea, when other first-line antibiotics are not suitable or when the bacteria show susceptibility to fleroxacin.

It's important to note that the use of fleroxacin and other fluoroquinolone antibiotics should be guided by appropriate susceptibility testing to ensure that the bacteria causing the infection are susceptible to the drug. The choice of antibiotic should also take into consideration local resistance patterns and individual patient factors.

Due to concerns about antibiotic resistance and potential side effects, fluoroquinolones are generally reserved for specific indications and used when other, more narrow-spectrum antibiotics are not effective. Additionally, fluoroquinolones, including fleroxacin, should be used judiciously to minimize the risk of developing bacterial resistance and serious side effects associated with this class of antibiotics. As with any prescription medication, it's essential to follow the healthcare professional's instructions, complete the full course of treatment, and report any adverse effects during fleroxacin therapy.

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